Quercetin Caused Redox Homeostasis Imbalance and Activated the Kynurenine Pathway
نویسندگان
چکیده
منابع مشابه
The Kynurenine Pathway
The kynurenine pathway represents a major route for the catabolism of tryptophan (TRP). In the body, TRP is transported around the periphery either bound to albumin (90%) or in free form (10%), the two states existing in equilibrium (McMenamy 1965). However, only free form TRP can be transported across the blood-brain barrier (BBB) by the competitive and nonspecific L-type amino acid transporte...
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1Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China 2Department of Neurology, Xijing Hospital, The Fourth Military Medicine University, Xi’an 710032, China 3School of Dentistry, Cardiff Institute of Tissue Engineering and Repair, Cardiff University, Heath Park, Cardiff CF14 4XY, UK 4Department of Neurology, Henry Ford Hospital, Detroit, MI 482...
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Suicide is a major global problem, claiming more than 800,000 lives annually. The neurobiological changes that underlie suicidal ideation and behavior are not fully understood. Suicidal patients have been shown to display elevated levels of inflammation both in the central nervous system and the peripheral blood. A growing body of evidence suggests that inflammation is associated with a dysregu...
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Numerous biological processes are governed by the biological clock. Studies using Drosophila melanogaster (L.) are valuable that could be of importance for their effective applications on rodent studies. In this study, the beneficial role of quercetin (a flavonoid) on H2O2 induced stress in D. melanogaster was investigated. D. melanogaster flies were divided into four groups (group I - control,...
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Neuroactive metabolites of the kynurenine pathway (KP) of tryptophan degradation have been closely linked to the pathogenesis of several neurodegenerative diseases. Tryptophan is an essential amino acid required for protein synthesis, and in higher eukaryotes is also converted into the key neurotransmitters serotonin and tryptamine. However, in mammals >95% of tryptophan is metabolized through ...
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ژورنال
عنوان ژورنال: Biology
سال: 2020
ISSN: 2079-7737
DOI: 10.3390/biology9080219